Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association. Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM, St Hilaire C; American Heart Association Council on Genomic and Precision Medicine Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing.Circulation. 2024 Jun 17. doi: 10.1161/CIR.0000000000001254. PMID: 38881493

Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC). Ferrante EA, Cudrici CD, Rashidi M, Fu YP, Huffstutler R, Carney K, Chen MY, St Hilaire C, Smith K, Bagheri H, Katz JD, Ferreira CR, Gahl WA, Boehm M, Brofferio A.Vasc Med. 2024 Apr 3:1358863X241235669. doi: 10.1177/1358863X241235669. Online ahead of print.PMID: 38568107

gNR4Aly Link Bridging Cellular Metabolism, Lactylation, and Vascular Calcification. Cuevas RA, Behzadi P, St Hilaire C.Circ Res. 2024 May 24;134(11):1448-1450. doi: 10.1161/CIRCRESAHA.124.324572. Epub 2024 May 23.PMID: 38781306

Aging Two-Step: SOX9’s Influence on Vascular Stiffness and Senescence. Behzadi P, St Hilaire C.Circ Res. 2024 Feb 2;134(3):325-327. doi: 10.1161/CIRCRESAHA.124.324212. Epub 2024 Feb 1.PMID: 38300983 

Mast cell activation and degranulation in acute artery injury: A target for post-operative therapy. Harper RL, Fang F, San H, Negro A, St Hilaire C, Yang D, Chen G, Yu Z, Dmitrieva NI, Lanzer J, Davaine JM, Schwartzbeck R, Walts AD, Kovacic JC, Boehm M.FASEB J. 2023 Jul;37(7):e23029. doi: 10.1096/fj.202201745RR.PMID: 37310585

Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress. Kroll RG, Powell C, Chen J, Snider NT, St Hilaire C, Reddy A, Kim J, Pinsky DJ, Murthy VL, Sutton NR. J Am Heart Assoc. 2023 May 2;12(9):e027920. doi: 10.1161/JAHA.122.027920. Epub 2023 Apr 29. PMID: 37119076.

Lnc’ing Metabolic Regulation of Epigenetic Modifications to Atherosclerotic Calcification. Cuevas RA, St Hilaire C. Circ Res. 2022 May 13;130(10):1583-1585. doi: 10.1161/CIRCRESAHA.122.321142. Epub 2022 May 12. PMID: 35549370.

Medial Arterial Calcification: A Significant and Independent Contributor of Peripheral Artery Disease.St Hilaire C. Arterioscler Thromb Vasc Biol. 2022 Jan 27:ATVBAHA121316252. doi: 10.1161/ATVBAHA.121.316252. Online ahead of print.PMID: 3508172

Editorial: Comorbidities and Aortic Valve Stenosis: Molecular Mechanism, Risk Factors and Novel Therapeutic Options. St Hilaire C, Jansen F, Goettsch C.Front Cardiovasc Med. 2022 Jan 4;8:811310. doi: 10.3389/fcvm.2021.811310. eCollection 2021.PMID: 35059452

Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence. Li Y, Kračun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S, St Hilaire C, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ.Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2015666118. doi: 10.1073/pnas.2015666118.PMID: 34654740

Medial Arterial Calcification: JACC State-of-the-Art Review. Lanzer P, Hannan FM, Lanzer JD, Janzen J, Raggi P, Furniss D, Schuchardt M, Thakker R, Fok PW, Saez-Rodriguez J, Millan A, Sato Y, Ferraresi R, Virmani R, St Hilaire C.J Am Coll Cardiol. 2021 Sep 14;78(11):1145-1165. doi: 10.1016/j.jacc.2021.06.049.PMID: 34503684

Building Your Mentoring Network in Your Early Career. Ouimet M, Bauer RC, St Hilaire C.Arterioscler Thromb Vasc Biol. 2021 Oct;41(10):2513-2515. doi: 10.1161/ATVBAHA.121.316802. Epub 2021 Aug 26.PMID: 34433295

Isolation of Human Primary Valve Cells for In vitro Disease Modeling. Cuevas RA, Chu CC, Moorhead WJ 3rd, Wong R, Sultan I, St Hilaire C.J Vis Exp. 2021 Apr 16;(170):10.3791/62439. doi: 10.3791/62439.PMID: 33938898

Introduction to the Aortic Valve Disease Review Series. Cuevas RA, St Hilaire C.Circ Res. 2021 Apr 30;128(9):1327-1329. doi: 10.1161/CIRCRESAHA.121.319286. Epub 2021 Apr 29.PMID: 33914602

Multifocal calcific periarthritis with distinctive clinical and radiological features in patients with CD73 deficiency. Cudrici CD, Newman KA, Ferrante EA, Huffstutler R, Carney K, Betancourt B, Miettinen M, Siegel R, Katz JD, Nesti LJ, St Hilaire C, Lakshmipathy D, Wen H, Bagheri MH, Boehm M, Brofferio A.Rheumatology (Oxford). 2021 Dec 24;61(1):163-173. doi: 10.1093/rheumatology/keab270.PMID: 33744914

Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease. Moorhead WJ 3rd, Chu CC, Cuevas RA, Callahan J 4th, Wong R, Regan C, Boufford CK, Sur S, Liu M, Gomez D, MacTaggart JN, Kamenskiy A, Boehm M, St Hilaire C.Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1680-1694. doi: 10.1161/ATVBAHA.119.313765. Epub 2020 May 7.PMID: 32375544

Retinoids: Dissolving the Calcification Paradox. St Hilaire C.Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):503-505. doi: 10.1161/ATVBAHA.119.313854. Epub 2020 Feb 26.PMID: 32101475

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5. Carlsten M, Namazi A, Reger R, Levy E, Berg M, St Hilaire C, Childs RW.Oncoimmunology. 2018 Nov 2;8(2):e1534664. doi: 10.1080/2162402X.2018.1534664. eCollection 2019.PMID: 30713790

CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans. Joolharzadeh P, St Hilaire C.Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):339-348. doi: 10.1161/ATVBAHA.118.311579.PMID: 30676071

Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture. Xue Y, St Hilaire C, Hortells L, Phillippi JA, Sant V, Sant S.Cell Mol Bioeng. 2017 Oct;10(5):483-500. doi: 10.1007/s12195-017-0495-6. Epub 2017 Jul 25.PMID: 30319717

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice. Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St Hilaire C, Müller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK.Nat Med. 2018 Sep;24(9):1418-1429. doi: 10.1038/s41591-018-0124-5. Epub 2018 Jul 23.PMID: 30038218

Cell Phenotype Transitions in Cardiovascular Calcification. Hortells L, Sur S, St Hilaire C.Front Cardiovasc Med. 2018 Mar 26;5:27. doi: 10.3389/fcvm.2018.00027. eCollection 2018.PMID: 29632866

Abnormal molecular response to Takayasu arteritis causing extensive large-vessel calcification. Garland BT, Boehm M, Grayson PC, Hilaire CS, Brofferio A, Starnes BW.J Vasc Surg Cases Innov Tech. 2016 Dec;2(4):190-192. doi: 10.1016/j.jvscit.2016.05.004.PMID: 28748225

Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC. Jin H°, St Hilaire C°, Huang Y°, Yang D, Dmitrieva NI, Negro A, Schwartzbeck R, Liu Y, Yu Z, Walts A, Davaine JM, Lee DY, Donahue D, Hsu KS, Chen J, Cheng T, Gahl W, Chen G, Boehm M.Sci Signal. 2016 Dec 13;9(458):ra121. doi: 10.1126/scisignal.aaf9109.PMID: 27965423 °denotes equal contribution

Catching a Disease: A Molecular Trap as a Therapy for Pulmonary Arterial Hypertension. Roman BL, St Hilaire C.Am J Respir Crit Care Med. 2016 Nov 1;194(9):1047-1049. doi: 10.1164/rccm.201605-0920ED.PMID: 27797615

Bidirectional Translation in Cardiovascular Calcification. St Hilaire C, Liberman M, Miller JD; Early Career Committee.Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):e19-24. doi: 10.1161/ATVBAHA.115.307056.PMID: 26912744

Activated STING in a vascular and pulmonary syndrome. Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R.N Engl J Med. 2014 Aug 7;371(6):507-518. doi: 10.1056/NEJMoa1312625. Epub 2014 Jul 16.PMID: 25029335

Medial vascular calcification revisited: review and perspectives. Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller T, St Hilaire C, Shanahan C.Eur Heart J. 2014 Jun 14;35(23):1515-25. doi: 10.1093/eurheartj/ehu163. Epub 2014 Apr 16.PMID: 24740885

TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M.Sci Transl Med. 2014 Mar 12;6(227):227ra34. doi: 10.1126/scitranslmed.3006927.PMID: 24622514

Commentary: D. James, S. Rafii. Maladapted Endothelial Cells Flip the Mesenchymal Switch. Sci Transl Med. 2014 Mar 12;6(227):227fs12

NT5E mutations and arterial calcifications. St Hilaire Cº, Ziegler SGº, Markello TCº, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WAº, Boehm Mº. N Engl J Med. 2011 Feb 3;364(5):432-42. doi: 10.1056/NEJMoa0912923.PMID: 21288095  °denotes equal contribution

Correspondence: Boehm M., St. Hilaire C., Gahl W.A. NT5E mutations and Arterial Calcifications. N Engl J Med. 2011 364: 1577-1580

This paper was highlighted in 20+ articles, including:

Genomics Reaches the Clinic: From Basic Discoveries to Clinical Impact. Cell 2011

He’s no Gregory House — Which is a Good Thing. Scientific American November 1, 2011

Medical Detectives Find Their First New Disease. New York Times, February 3, 2011, page A3

Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum. Markello TC, Pak LK, St Hilaire C, Dorward H, Ziegler SG, Chen MY, Chaganti K, Nussbaum RL, Boehm M, Gahl WA.Mol Genet Metab. 2011 May;103(1):44-50. doi: 10.1016/j.ymgme.2011.01.018. Epub 2011 Feb 3.PMID: 21371928

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St Hilaire C, Boehm M.J Clin Invest. 2010 Jan;120(1):303-14. doi: 10.1172/JCI40364. Epub 2009 Dec 28.PMID: 20038813

Commentary: Hla T and Oo ML. Ramping up RANTES in the acute response to arterial injury J Clin Invest. 2010 Jan;120(1):90–92.

Mechanisms of induction of adenosine receptor genes and its functional significance. St Hilaire C, Carroll SH, Chen H, Ravid K.J Cell Physiol. 2009 Jan;218(1):35-44. doi: 10.1002/jcp.21579.PMID: 18767039

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis. Nguyen HG, Makitalo M, Yang D, Chinnappan D, St Hilaire C, Ravid K.FASEB J. 2009 Aug;23(8):2741-8. doi: 10.1096/fj.09-130963. Epub 2009 Mar 30.PMID: 1933264

B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. St Hilaire C, Yang D, Schreiber BM, Ravid K.J Cell Biochem. 2008 Apr 15;103(6):1962-74. doi: 10.1002/jcb.21586.PMID: 17979185

TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. St Hilaire C, Koupenova M, Carroll SH, Smith BD, Ravid K.Biochem Biophys Res Commun. 2008 Oct 24;375(3):292-6. doi: 10.1016/j.bbrc.2008.07.059. Epub 2008 Jul 21.PMID: 18647598

Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation.Hurtad o PA, Vora S, Sume SS, Yang D, St Hilaire C, Guo Y, Palamakumbura AH, Schreiber BM, Ravid K, Trackman PC.Biochem Biophys Res Commun. 2008 Feb 1;366(1):156-61. doi: 10.1016/j.bbrc.2007.11.116. Epub 2007 Dec 3.PMID: 18060869

Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Yang D, McCrann DJ, Nguyen H, St Hilaire C, DePinho RA, Jones MR, Ravid K.Aging Cell. 2007 Apr;6(2):257-60. doi: 10.1111/j.1474-9726.2007.00274.x. Epub 2007 Feb 7.PMID: 17291294

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K.J Clin Invest. 2006 Jul;116(7):1913-23. doi: 10.1172/JCI27933.PMID: 16823489

Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Hazony Y, Lu J, St Hilaire C, Ravid K.Nucleic Acids Res. 2006;34(16):4416-28. doi: 10.1093/nar/gkl578. Epub 2006 Aug 26.PMID: 16936310

Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Nagata Y, Jones MR, Nguyen HG, McCrann DJ, St Hilaire C, Schreiber BM, Hashimoto A, Inagaki M, Earnshaw WC, Todokoro K, Ravid K.Exp Cell Res. 2005 May 1;305(2):277-91. doi: 10.1016/j.yexcr.2004.12.028.PMID: 15817153

Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Al-Baradie R, Yamada K, St Hilaire C, Chan WM, Andrews C, McIntosh N, Nakano M, Martonyi EJ, Raymond WR, Okumura S, Okihiro MM, Engle EC.Am J Hum Genet. 2002 Nov;71(5):1195-9. doi: 10.1086/343821. Epub 2002 Oct 22.PMID: 12395297